LP1845 Liquid Gun Propellant Dermal Toxicity Studies: Evaluation of the Potential of LP1846 Liquid Gun Propellant to Induce Unscheduled DNA Synthesis in the in Vitro Hepatocyte DNA Repair Assay

Abstract

The contractor assessed the ability of the test material, LP 1846 Liquid Gun Propellant (LP1846), to induce unscheduled DNA synthesis (UDS) in primary cultures of male Fischer-344 (F-344) rat hepatocytes. Compound LP1846 was tested at concentrations of 0.5, 1, 5, 10, 50, 100, 250, 500,1000, 2500, and 5000 ug/ml. No increase in UDS above that of the media control level was observed after treatment of the hepatocytes with compound LP1846. Therefore, on the basis of our criterion for a positive response, LP1846 was negative in the in vitro rat hepatocyte DNA repair assay. Keywords: Liquid gun propellants; UDS; In vitro analysis; Rat hepatocytes; Genotoxicity; DNA repair; Bioassay; Liver.

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Document Details

Document Type
Technical Report
Publication Date
Mar 14, 1990
Accession Number
ADA219648

Entities

People

  • James P. Bakke
  • Robert Finch

Organizations

  • SRI International

Tags

DTIC Thesaurus Topics

  • Animals
  • Biological Sciences
  • Cells
  • Chemistry
  • Culture Techniques
  • Data Analysis
  • Databases
  • Environmental Protection
  • Epithelial Cells
  • Eukaryotes
  • Gun Propellants
  • Laboratory Animals
  • Liquid Gun Propellants
  • Materials
  • Medical Personnel
  • Personnel Management
  • Propellants

Fields of Study

  • Biology

Readers

  • Immunology
  • Toxicology/Environmental Toxicology
  • ballistics.

Technology Areas

  • Biotechnology
  • Biotechnology - Bioremediation