Effects of Cholinergic Perturbations on Neuromotor - Cognitive Performance
Abstract
In a continuing effort to document, systematically, the dose dependent effect of atropine in man (in the absence of an organophosphate challenge), we have evaluated a new series of cognitive-neuromotor tasks. In the confusion of military encounters in a combat environment, large numbers of personnel could potentially self-administer 2.0-6.0 mg of atropine when there is a misinterpretation of events and/or there is an over-reaction resulting in multiple injections within a short period of time. Indeed, multiple doses of atropine alone may be utilized rationally as a prophylactic under certain conditions. This research document is aimed at specific drug-induced changes at the neuromotor, cognitive and physiological level, has resulted in a series of studies utilizing recently developed tests comparing the atropine sensitivity of these new tests and earlier studies evaluated in our lab. Keywords: Drugs; Response biology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA219871
Entities
People
- A. M. Nikaido
- D. G. Heatherly
- E. H. Ellinwood
- J. K. Nishita
- Salil Gupta
Organizations
- Duke University Hospital