Testing of Experimental Compounds for Efficacy against Leishmania
Abstract
Six of a total of 312 compounds of diverse nature which were tested in the primary visceral screening system were noted to have suppressive activity against Leishmania donovani (suppressed parasite numbers in the liver by at least 50% at one of the dosages used). The 8-aminoquinolines were the most active compounds studied with approximately 100% suppression of hepatic parasites at 52 mg/kg dosage. Pyrimidine nucleotides had relatively low efficacy as has been noted with this group of compounds in the past. One of 250 pyrazine or quinazoline inhibitors of dihydrofolate reductase which were tested was active. Results of special studies with combinations of Sinefungin and selected purine analogs indicated that when Sinefungin was administered to hamsters infected with L. donovani alone or in combination with any one of six selected purine analogs, no antiparasitic activity significantly greater than that attributable to Sinefungin alone was observed. Keywords: Leishmania donovani; Chemotherapy; Golden hamster; WR06026; Berberine; Sinefungin; RA 1; Pyrimidine nucleotides; Antileishmanials.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 28, 1990
- Accession Number
- ADA219986
Entities
People
- Virginia B. Waits
- William L. Hanson
- Willie L. Chapman Jr.
Organizations
- University of Georgia Research Foundation