Effects of Cholinergic Perturbations on Neuromotor - Cognitive Performance
Abstract
Atropine dosing ranging from 0.5 to 4.0 mg demonstrated significant cognitive-neuromotor impairment effects in the 2.0 and 4.0 mg dose. The effects shown after the 4.0 mg dose was of a much greater magnitude and duration than that of the 2.0 mg dose. However, all dose of atropine induced significant tachycardia which declined much more rapidly than performance measures. The pharmacokinetics of I.M. atropine can be best described by a two-compartment with very fast first order adsorption. For all doses, atropine plasma levels and heart rate changes closely overlapped throughout the time course. In contrast, the differential time course of changes in atropine levels and behavioral impairment indicates that pharmacokinetics is not the primary rate limiting mechanism for brain effects of atropine. Potential differences in time course effects on M1 vs M2 receptors raise the question of whether some of the protective effects of atropine may not be maintained as long as other effects.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1988
- Accession Number
- ADA219998
Entities
People
- A. M. Nikaido
- D. G. Heatherly
- E. H. Ellinwood
- J. K. Nishita
- Salil Gupta
Organizations
- Duke University Hospital