Analysis of Neural Systems Involved in Modulation of Memory Storage
Abstract
The research supported by this contract over the past three years examined the role of neuromodulatory systems in the modulation of memory storage processes. The research was based on extensive evidence from previous studies indicated that memory storage processes are modulated by neuromodulatory systems activated by learning experiences. It is well documented that, in laboratory animals, retention is modified by post training administration of stress-related hormones as well as neruotransmitters and drugs that influence hormonal and neurotransmitter systems. Research in the laboratory has examined the effects of treatments affecting adrenergic, cholinergic, opioid peptidergic and, most recently, GABAergic systems. Previous studies indicated that these neuromodulatory systems may influence memory through effects involving the amygdaloid complex. More generally, the findings of preliminary studies suggested that the amygdala may serve to integrate the effects of neuromodulatory systems on memory storage. The aim of the research supported by this contract was, (1) to increase our understanding of the locus of brain regions involved in the effects, on memory of treatments affecting neuromodulatory systems, and (2) to determine whether treatments affecting memory storage work through a common set of brain systems. (AW)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA220230
Entities
People
- James L. Mcgaugh
Organizations
- University of California, Irvine