Biological Significance of the Immune Response to HTLV-III/LAV

Abstract

It has been shown that the major neutralizing determinant of HIV lies in the V3 segment of gp120, coded by a dominant, hypervariable region. A cocktail of V3 peptides will elicit, reproducibly, high anti-peptide and anti- HIV neutralizing activity for each isolate included in the cocktail. (KT)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1989
Accession Number
ADA220335

Entities

People

  • Dani P. Bolognesi

Organizations

  • Duke University Hospital

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Blood
  • Cells
  • Chemical Reactions
  • Classification
  • Contracts
  • Hiv Infections
  • Infection
  • Laboratory Animals
  • Macrophages
  • Materials
  • Monocytes
  • Polymerase Chain Reaction
  • Security
  • Vaccines
  • Viruses
  • Wound Infections

Fields of Study

  • Physics

Readers

  • Immunology
  • Molecular and Cellular Biochemistry