Therapeutic Approaches to the Treatment of Botulism

Abstract

Research has been conducted in four areas that pertain to the development of antagonists of botulinum neurotoxin, as follows: 1) Studies on monoclonal antibodies indicate that they are useful research tools, but they appear to have little therapeutic potential. 2) Research on aminopyridines and their analogues shows that they possess anti-botulinum activity, but only of a narrow utility. 3) Experiments with dendrotoxin have resulted in the provocative finding that this agent does not antagonize any clostridial toxin, nor does it reverse the effects of low calcium or high magnesium. 4) Initial studies on rubidium flux indicate that this may represent a rational approach for finding clostridial toxin antagonists. Keywords: Botulinum neurotoxin; Neuromuscular blockade; Experimental therapeutics.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1989
Accession Number
ADA220725

Entities

People

  • Lance L. Simpson

Organizations

  • Thomas Jefferson University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amines
  • Amino Acids
  • Analogs
  • Anesthesia
  • Biomedical Research
  • Botulism
  • Cells
  • Chemistry
  • Elements
  • Guanidines
  • Laboratory Animals
  • Methylamine
  • Nerves
  • Neuromuscular Transmission
  • Peripheral Nervous System
  • Phrenic Nerves
  • Rubidium

Readers

  • Microbial Pathology
  • Neuroscience
  • Theoretical Analysis.