Involvement of Prostaglandins and Histamine in Radiation-Induced Temperature Responses in Rats

Abstract

Exposure of rats to Gy of gamma radiation induced hypothermia, whereas exposure to 20-150 Gy produced hypothermia. Since radiation exposure included the release of prostaglandins (PGs) and histamine, the role of PGs and histamine in radiation-induced temperature changes was examined. Radiation- induced hyper- and hypothermia were antagonized by pretreatment with indomethacin, a cyclooxygenase inhibitor. Consistent with an apparent role of histamine in hypothermia, administration of disodium cromoglycate (a mast cell stabilizer), mepyramine (H1-receptor antagonist), or cimetidine (H2-receptor antagonist) attenuated PGD2- and radiation-induced hypothermia. These results suggest that radiation-induced hyperthermia is mediated via PGE2 and that radiation-induced hypothermia is mediated by another PG, possibly PGD2, via histamine. Keywords: Ionizing radiation; Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA220808

Entities

People

  • Sathasiva B. Kandasamy
  • Walter A. Hunt

Organizations

  • Armed Forces Radiobiology Research Institute

Tags

Communities of Interest

  • Counter IED

DTIC Thesaurus Topics

  • Animals
  • Body Temperature
  • Brain
  • Cells
  • Chemistry
  • Climate Change
  • Enzyme Inhibitors
  • Gamma Rays
  • Hyperthermia
  • Hypothermia
  • Induced Hyperthermia
  • Ionizing Radiation
  • Lagomorphs
  • Mast Cells
  • Peptides
  • Radiation
  • Rodents

Fields of Study

  • Medicine
  • Physics

Readers

  • Cardiovascular Physiology
  • Immunology and Pathology
  • Nuclear and Radiation Engineering.