Alterations in Brain Monoamine Neurotransmitter Release at High Pressure

Abstract

High pressure exposure produces neurological changes which manifest as tremors, EEG changes and convulsions. Since previous studies have implicated the involvement of the monoaminergic system in these symptoms, it was of interest to study monoamine release at high pressure. Synaptosomes isolated from guinea pig brain were used to follow monoamine efflux at 68 ATA. The major observation was a decrease in the initial calcium dependent release of all three monoamines in response to K+ induced depolarization. This response is similar to that previously observed for GABA, glycine and glutamate. This generalized pressure induced depression of initial transmitter release suggests a mechanism common to the release process for both excitatory and inhibitory neurotransmission. Keywords: Neurotransmitter; High pressure nervous syndrome; Synaptosomes; Monoamines; Hyperbaric pressure; Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1989
Accession Number
ADA220960

Entities

People

  • A. J. Dutka
  • J. S. Colton
  • S. C. Gilman

Organizations

  • Naval Medical Research Center

Tags

DTIC Thesaurus Topics

  • Biomedical Research
  • Brain
  • Chambers
  • Chemistry
  • Compression
  • Depolarization
  • Depression
  • Dopamine
  • Elements
  • High Pressure
  • Hyperbaric Chambers
  • Nerves
  • Nervous System
  • Neurotransmitters
  • Norepinephrine
  • Pressurization
  • Rodents

Fields of Study

  • Medicine

Readers

  • Neuroscience