Structure and Design of Multipotent Peptide Microbicides
Abstract
Defensin peptides, naturally occurring neutrophil antibiotics, were purified and characterized functionally and structurally. Functional differences in microbicidal potency and spectrum were correlated with structural features resolved by NMR and crystallographic methods. Protocols were established for synthesis and disulfide formation of natural defensins and synthetic congeners; we are currently investigating the latter by structural and functional characterization. Peptides, Structure-activity relationships, Synthesis, Microbicides, Antimicrobial peptides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 19, 1990
- Accession Number
- ADA220995
Entities
People
- Michael E. Selsted
Organizations
- University of California, Los Angeles