Strategies to Sustain and Enhance Performance in Stressful Environments

Abstract

Tyrosine, a large neutral amino acid normally present in protein foods, is the precursor of the catecholamine neurotransmitters dopamine, norepinephrine, and epinephrine. Animal studies indicate that systemic administration of tyrosine in pharmacologic quantities can reduce physiological and behavioral decrements induced by highly stressful conditions. The current study was designed to test the effects of tyrosine on humans exposed to cardiovascular stress. Physiological (HR, BP, AER, EOG, & EMG) and Behavioral (Rt, Mood, & Vigilance) indices were monitored during testing. Comparisons indicate that the effects of tyrosine ingestion include: 1) overall increase in pulse pressure (LBNP typically reduces pulse pressure). 2) an increase in P300 amplitude (indicating increased cognitive activity) when participating in the odd-ball task. 3) a non-significant increase (22%) in LBNP tolerance among subjects who could not withstand LBNP for the full 30 minute period. Results of this study indicate that elevated blood plasma tyrosine levels reduce physiological decrements caused by LBNP stress. Keywords: Tyrosine; Large Neutral Amino Acids(LNAA); Lower Body Negative Pressure(LBNP); Pulse.

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Document Details

Document Type
Technical Report
Publication Date
Mar 14, 1990
Accession Number
ADA221224

Entities

People

  • Andrew B. Dollins
  • Harris R Lieberman
  • Richard J. Wurtman

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Blood
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Catecholamines
  • Chemical Synthesis
  • Chemistry
  • Computers
  • Health Services
  • Heart Rate
  • Information Processing
  • Medical Personnel
  • Neutral Amino Acids
  • Reaction Time

Fields of Study

  • Biology

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Cardiovascular Physiology
  • Psychological Intervention/Treatment for Stress, Anxiety, PTSD, and Related Emotional and Cognitive Health Symptoms.