The Role of Chemical Inhibition of Gap-Junctional Intercellular Communication in Toxicology
Abstract
Progress during the first 12 months of this grant has progressed on all six specific aims, namely to study the basic mechanisms by which toxic chemicals block cell-cell communication; role of oncogenes in down-regulating gap junctional intercellular communication (GJIC); how protein kinase C enzyme, after activated by chemicals, down regulates GJIC; validate known toxic chemicals' ability to block GJIC in new human cell lines; isolate gap junction antibodies to characterize and study how gap junctions are regulated; and to isolate and characterize gap junction mutants. Several experimental, theoretical and review articles have been submitted. Presented research at recent international meetings and several national meetings. Gap junctions; Cell communication; Tumor promoters; Teratogens; Neurotoxins; Protein kinase C; Chemical toxicity; Biochemistry; Carcinogens.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1990
- Accession Number
- ADA221480
Entities
People
- James E. Trosko
Organizations
- Michigan State University