Chemoprophylaxis and Antidotal Efficacy of Alpha-Ketoglutaric Acid in Hydrogen Cyanide Poisoning
Abstract
The purpose of this project is primarily to establish a model system for exposing animals (mice and rats) to hydrogen cyanide (HCN). A chamber has been designed, constructed and tested for the nose-only dynamic exposure of rats to HCN. A chamber of two compartments is available for exposure of mice to HCN after allowing the chamber to equilibrate. Analytical methods (microdiffusion and gas chromatography) for the determination of cyanide (CN) levels in blood and chamber air are established and confirmed. A method, employing selective ion electrode, is being used to monitor the test solutions fo cyanide salts. Subject terms: Cyanide; Exposure chamber; Antidotes; Alpha-ketoglutaric acid.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 13, 1989
- Accession Number
- ADA221531
Entities
People
- Arthur S. Hume
Organizations
- University of Mississippi Medical Center