Genetic Analysis of the Presentation of Minor Lymphocyte-Stimulating Determinants. 2. Differing Non-MHC Control of Super-Stimulatory and more Poorly Stimulatory Mis Phenotypes

Abstract

Analysis of the capacity of splenocytes from non-prototypic M1sa or M1sc mouse strains to stimulate allogenic H-2k-compatible T cells in a primary M1s-defined MLR provided interesting examples of exceptions to the usually stated characterization of M1sa and M1sc determinants as highly stimulatory or weakly stimulatory, respectively. Across the M1sa barrier, MA/My stimulator cells had a significantly reduced capacity to elicit responder proliferation in comparison with prototypic AKR/J or less well studied C58/J, CE/J, or RF/J splenocytes being virtually non-stimulatory, prototypic C3H/HeJ splenocytes having an intermediate capacity, and CE/J and C58/J being highly stimulatory presenters of this non-MHC specificity. Reprints.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1990
Accession Number
ADA221536

Entities

People

  • Fred D. Finkelman
  • H. B. Lejeune
  • James J. Mond
  • John J. Ryan

Organizations

  • Naval Medical Research Center

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • B Lymphocytes
  • Biomedical Research
  • Cell Division
  • Cell Line
  • Cells
  • Genes
  • Genetics
  • Growth Factors
  • Leukocytes
  • Lymphatic System
  • Lymphocytes
  • Molecules
  • Navy
  • Phenotypes
  • Recognition

Fields of Study

  • Biology

Readers

  • Aquatic Ecology
  • Immunology
  • Oncology (Cancer Research).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech