Respiratory Sinus Arrhythmia: A Potential Indicator of Cholinergic Toxicosis in Rhesus Monkeys (Macaca mulatta)

Abstract

The vagal tone monitor (VTM) is being studied as a noninvasive tool for detecting organophosphate exposures and monitoring anticholinergic therapies. This study evaluated the VTM responses of rhesus monkeys (Macaca mulatta) after intramuscular injections of atropine sulfate, pyridostigmine bromide, physostigmine salicylate, and combinations of atropine and pyridostigmine. The VTM analyses of the electrocardiogram data yielded heart period (HP), heart period variance (HPV), and the estimate of vagal tone (V). Statistical analyses indicated that HP was more sensitive to pyridostigmine than to physostigmine, while V responded more to physostigmine and atropine than to pyridostigmine.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA221680

Entities

People

  • Bruce C. Richardson
  • David J. Zaber
  • Heiko T. Jansen
  • John A. Dellinger
  • Shari Birnbaum

Organizations

  • University of Illinois Urbana–Champaign

Tags

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Cardiac Arrhythmias
  • Cardiovascular Physiological Phenomena
  • Cardiovascular System
  • Electrocardiography
  • Erythrocytes
  • Health Services
  • Heart Rate
  • Information Processing
  • Information Science
  • Intramuscular Injections
  • Medical Personnel
  • Nervous System
  • Pyridostigmine Bromide
  • Rhesus Monkeys
  • Statistical Analysis

Fields of Study

  • Biology
  • Psychology

Readers

  • Cardiovascular Physiology
  • Neurotoxicology
  • Toxicology/Environmental Toxicology