Pathobiology of HTLV-III/LAV In Human Monocyte-Macrophage

Abstract

We have studied the pathobiology of human immunodeficiency virus (HIV) in human monocyte-macrophages. The role of cytokines released following HIV infection of these target cells, potentially with exposure to physiologic stimuli such as endotoxin, as well as the effects of cytokines on regulation of HIV replication have been pursued. The biochemical basis of control of HIV replication within monocytes has been examined by studying cell signaling events. In addition, the effects of HIV on hematopoietic stem cells has been explored. These studies may improve our understanding of dysregulation of myeloid cell function in AIDS and thus provide the framework for improved therapeutic strategies for this disease.

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Document Details

Document Type
Technical Report
Publication Date
Apr 14, 1990
Accession Number
ADA221724

Entities

People

  • Jerome E. Groopman

Organizations

  • Beth Israel Deaconess Medical Center

Tags

DTIC Thesaurus Topics

  • Biological Factors
  • Blood
  • Bone Marrow
  • Cells
  • Chemistry
  • Health Services
  • Hiv Infections
  • Infectious Diseases
  • Lymphocytes
  • Macrophages
  • Medical Personnel
  • Monocytes
  • Myeloid Cells
  • Peptides
  • Proteins
  • Stem Cells
  • Therapy

Fields of Study

  • Biology
  • Medicine

Readers

  • Immunology
  • Immunology and Pathology

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech