The Role of Neuropeptides in Persistent Virus Infections of the Central Nervous System
Abstract
A temperature-sensitive (ts) mutant of vesicular stomatitis virus (VSV), tsG31 KS5, engendered a slowly progressive paralytic central nervous system (CNS) disease that killed all Balb/c nude mice within 28 days. Reconstitution of nude mice with 107 syngeneic splenocytes 24 h before intracerebral inoculation with tsG31 KS5 VSV, however, protected 92% of the animals from death. When these reconstituted animals were injected intracerebroventricularly with 14 pmol of endorphin 24 h after reconstitution with splenocytes and 24 h before inoculation with tsG31 KS5 VSV, only 72% of the animals survived. Opioids, Lymphocytes, Infections, Nervous system, Virus, Immunity, Neuropeptides.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 10, 1990
- Accession Number
- ADA221845
Entities
People
- Terry C. Johnson
Organizations
- Kansas State University