Assessment of the Developmental Toxicity of Propylene Glycol Monomethyl Ether Acetate (PM Acetate) in Rats

Abstract

This study evaluated the potential maternal, embryotoxic and teratogenic parameters of propylene glycol monomethyl ether acetate in Sprague- Dawley rats following inhalation of vapors in days 6-15 of gestation. No teratological or other developmental effects were seen in fetuses at air concentrations as high as 4000 parts per million, in spite of slight toxic effects in dams at concentrations as low as 500 ppm. It is recommended that a) an interim Workplace Exposure Limit be established at 100 ppm with a Short Term Exposure Limit of 150 ppm, b) the beta isomer constitutes no more than 3 percent of the total PM Acetate in all military specifications, c) an inhalation developmental study be performed in the rabbit, and d) workers be monitored for the central nervous system and irritation effects. Teratology, Teratogenic, Rats, Inhalation, PM acetate, Propylene glycol monomethyl ether acetate, Propylene glycol methyl ether acetate, Biochemistry, Toxic hazards.

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1989
Accession Number
ADA221988

Entities

People

  • Arthur E. Asaki
  • John T. Houpt

Organizations

  • United States Army Medical Command

Tags

DTIC Thesaurus Topics

  • Alcohols
  • Arteries
  • Body Weight
  • Central Nervous System
  • Chemical Warfare Agents
  • Chemistry
  • Ethers
  • Glycols
  • Health Services
  • Hygiene
  • Nervous System
  • Pilot Studies
  • Propenes
  • Propylene Glycol
  • Rodents
  • Specifications
  • Toxicity

Readers

  • Polymer Science and Engineering.
  • Toxicology/Environmental Toxicology