The Acute, Delayed Neurotoxicity Evaluation of Two Jet Engine Oil Formulations

Abstract

This study was designed to determine the potential of two jet oils to produce acute, delayed neurotoxicity. The hydrocarbon-based ester oil formulation contained 3% tricresyl phosphate isomers, including triorthocresyl phosphate (TOCP) in one of the formulations. Hens were orally dosed over a five- day period and then observed for a total period of 30 days. All TOCP-positive control hens demonstrated signs of acute, delayed neurotoxicity. Hens from both jet engine oil groups remained asymptomatic throughout the observation period. No neurotoxic hazard would be expected for military or civilian personnel involved in the manufacture, transportation, or handling of these compounds. Keywords: Engine oils; Lubricating oils; Neurotoxicity.

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Document Details

Document Type
Technical Report
Publication Date
Apr 01, 1990
Accession Number
ADA222018

Entities

People

  • E. R. Kinkead
  • H. G. Wall
  • R. E. Wolfe
  • S. R. Bunger

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Biomedical Research
  • Body Weight
  • Carcinoma
  • Chemical Synthesis
  • Chemistry
  • Contracts
  • Corporations
  • Jet Engines
  • Laboratory Animals
  • Medical Personnel
  • Plant Oils
  • Sciatic Nerve
  • Specifications
  • Spinal Cord
  • Statistical Analysis
  • Toxic Hazards

Readers

  • Neurotoxicology
  • Petroleum Engineering
  • Toxicology/Environmental Toxicology