Anti-Cyanide Drugs

Abstract

The purpose of this project was to identify and develop prophylactic anti-cyanide agents including metal complexes, alkylidines, metalloporphyrins and aldehyde and ketone cyanohydrin formers. The screen involved pre- administration of drugs to mice at 15 and 60 minutes, followed by 2 lethal dose- 50s of potassium cyanide. Out of forty-three drugs, only nickel (II) chloride, cobalt(II)-chloride and 2-carboxybenzaldehyde survived the screen. The affinity of lower oxidation states of cyanocobalt(III)porphyrins and metal(ethylenediaminetetraacetic acid) adducts for cyanide was probed, and complexes that selectively release a cyanide specific metal upon demand were investigated. Keywords: Cyanide, Cyanide scavengers, Porphyrins, Metalloporphyrins, Cobalt, Cyanohydrins, Aldehydes, Ketones, Metal complexes, Nickel.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1989
Accession Number
ADA222511

Entities

People

  • Peter Hambright

Organizations

  • Howard University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Aldehydes
  • Biomedical Research
  • Body Weight
  • Chemical Synthesis
  • Chemistry
  • Classification
  • Contracts
  • Coordination Complexes
  • Lethal Dosage
  • Maryland
  • Metals
  • Molecules
  • Organic Chemistry
  • Oxidation
  • Phthalocyanines
  • Rodents
  • Security

Fields of Study

  • Chemistry

Readers

  • Distributed Systems and Data Platform Development
  • Neurotoxicology
  • Organic Chemistry