Organization and Expression of Plasmodial Genes Required for Erythrocyte Invasion
Abstract
The invasion of erythrocytes and sequestration of infected cells in the microvasculature enables P. falciparum to minimize its interaction with the host, resulting, however in the significant morbidity and mortality of falciparum malaria. The molecular basis for parasite sequestration involves a complex macrostructure elicited on the infected erythrocyte surface called the knob. The interaction of parasite and host proteins to form this structure and the genetic regulation of this structure has been investigated through the structural and functional analysis of knob associated proteins. The knob- associated histidine rich protein (KAHRP), together with parasite and host derived proteins interact to mediate cytoadherence. Characterization for the protein interactions which result in endothelial cell binding and the identification of parasite proteins involved in this phenotype have been studied through their interaction with the KAHRP. (JES)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 27, 1988
- Accession Number
- ADA222674
Entities
People
- Jeffrey Ravetch
Organizations
- Memorial Sloan Kettering Cancer Center