Neurobehavioral Effects of Carbon Monoxide (CO) Exposure in Humans: Elevated Carboxyhemoglobin (COHb) and Cerebrovascular Responses

Abstract

A two-channel cranial impedance plethysmograph (CIP) was designed and constructed as a noninvasive measure of brain blood flow (BBF) in man. The instrument was designed to reduce some of the problems with instability and difficulty of use found in earlier commercially-available models. The CIP has been previously validated against other measures of BBF. During carboxyhemoglobin (COHb) formation, BBF is known to increase. When BBF increases it compensates for the reduced ability of the blood to carry oxygen in the presence of COHb. Fifteen men breathed carbon monoxide (CO) to produce increases in COHb values ranging from endogenous 18.4%. (JES)

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Document Details

Document Type
Technical Report
Publication Date
May 19, 1989
Accession Number
ADA222840

Entities

People

  • James D. Prah
  • Matthew L. Petrovick
  • Vernon A. Benignus

Organizations

  • Environmental Protection Agency

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical

DTIC Thesaurus Topics

  • Biomedical Research
  • Blood
  • Blood Flow
  • Carbon Monoxide
  • Cardiovascular System
  • Databases
  • Dielectric Gases
  • Dynamic Range
  • Electrical Impedance
  • Environmental Protection
  • Health Services
  • Impedance
  • Materials
  • Measurement
  • Medical Personnel
  • Poisoning
  • Regression Analysis

Readers

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  • Life Cycle Cost Analysis
  • Marine Mammal Biology