Controlled Release of Antigens for One Dose Immunization

Abstract

The main objective of this study was to develop a biodegradable, controlled-release adjuvant system capable of eliminating the need for multistep vaccination schedules. This investigation was designed to: determine in an animal model hepatitis B vaccine release rate characteristics desirable for single-step immunization, incorporate those release rate characteristics into a one-step biodegradable poly(DL-lactide-co-glycolide) (DL-PLG) microencapsulated hepatitis B surface antigen (HBsAg) vaccine, and conduct an in vivo trial comparing the effectiveness of this single-step vaccine against the conventional three-step hepatitis vaccine currently employed. The results were intended to provide the foundation for further development of single step vaccines against hepatitis and other militarily significant diseases. Keywords: Pharmacology, Antigens, One-dose-immunization, Medicine, Vaccines.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1983
Accession Number
ADA222956

Entities

People

  • John E. Van Hamont

Organizations

  • United States Army Institute of Surgical Research

Tags

DTIC Thesaurus Topics

  • Albumins
  • Alcohols
  • Alkanes
  • Antigens
  • Chlorides
  • Encapsulation
  • Health Care
  • Health Services
  • Hepatitis
  • Immune System
  • Immunization
  • Laboratory Animals
  • Methanols
  • Microcapsules
  • Vaccination
  • Vaccines
  • Vacuum Chambers

Fields of Study

  • Biology

Readers

  • Combustion science or combustion engineering.
  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology