Reciprocal Expression of Human ETS1 and ETS2 Genes during T-Cell Activation: Regulatory Role for the Protooncogene ETS1
Abstract
The expression of the protooncogenes ETS1 and ETS2 has been studied in purified human T cells activated either by cross-linking of the T-cell receptor-CD3 complex on their cell surface or by direct stimulation with phorbol esters and ionomycin. Our results show that resting T cells express high levels of ETS1 mRNA and protein, while expression of ETS2 is undetectable. Upon T-cell activation, ETS2 mRNA and proteins are induced, while ETS1 gene expression decreases to very low levels. Late after stimulation, ETS1 mRNA is reinduced and maintained at a high level, while ETS2 gene expression decreases to undetectable levels. Therefore, it appears that in human T cells, ETS2 gene products are associated with cellular activation and proliferation, while ETS1 gene products are preferentially expressed in a quiescent state. Keywords: Reprints, Genetic studies, Human ETS1 and ETS2 genes, T-cell activation, Protooncogene ETS1, Regulatory role, C-ets gene family, Cell proliferation.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1990
- Accession Number
- ADA222964
Entities
People
- Carl H. June
- Craig. B. Thompson
- Narayan K. Bhat
- Shigeyoshi Fujiwara
- Tullia Lindsten
Organizations
- Naval Medical Research Center