Reaction of Cysteine(s) with Phenyldichloroarsine
Abstract
In order to further our studies dealing with the interaction of organic arsenicals with biological sulfhydryl-containing molecules, we investigated the reaction of phenyldichloroarsine with L-cysteine, and two derivatives of L-cysteine in methanol-d4. We found that cysteine (in contrast to glutathione in H2O) formed a mono-cysteine adduct when the L-Cys/PDA ratio was < or = 1:1 (2). When cysteine was present in two molar equivalents, the expected 2:1 adduct was formed via chelation of the two sulfur atoms of cysteine to the arsenic atom (3). Both L-cysteine methyl ester and N-acetyl-L-cysteine reacted like L-cysteine and formed a 1:1 adduct when the ratio was < or =. (jg)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1990
- Accession Number
- ADA223117
Entities
People
- Evelyn L. Mcgown
- Kilian Dill
- Richard J. O'connor
Organizations
- Letterman Army Hospital