Neuroendocrine Responses to Hypertonic Saline/Dextran Resuscitation
Abstract
The neuroendocrine responses to resuscitation with 7.5% hypertonic saline/6% Dextran-70 (HSD) following hemorrhagic hypotension were evaluated in conscious swine. Following hemorrhage, animals received 4 milliliters per kilogram of HSD (n=6) or 0.9% saline (n=8). Administration of normal saline did not alter cardiovascular function nor attenuate an increase in hormones, HSD rapidly improved cardiovascular function and acutely decreased ACTH, PRA (Plasma Renin Activity), cortisol, norepinephrine (NE), epinephrine (E), aldosterone and lysine vasopressin levels (LVP). The initial decrease in ACTH (adrenocorticotropic hormone), cortisol and aldosterone levels was due primarily to hemodilution associated with the expansion of plasma volume. The reductions in NE, E, LVP and PRA were greater than those attributed to hemodilution alone. Values for LVP, NE and E remained at values below those at the end of hemorrhage, but greater than basal levels, while PRA returned to values similar to these at the end of hemorrhage. (jg)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1990
- Accession Number
- ADA223184
Entities
People
- Charles E.W. Wade
- J. A. Loveday
- J. P. Hannon
- R. I. Coppes Jr.
- V. L. Gildengorin
Organizations
- Letterman Army Hospital