Oxygen Delivery and Demand in Conscious Pigs Subjected to Fixed-Volume Hemorrhage and Resuscitated with 7.5% NaCl in 6% Dextran
Abstract
A conscious porcine model was used to investigate the adequacy of oxygen delivery relative to O2 demand, initially during a fixed-volume hemorrhage and subsequently after resuscitation with 7.5% NaCl/6% Dextran. Hemorrhage produced a small increase in O2 consumption, severe lactacidemia, and a doubling of apparent O2 demand. These effects were attributable to a behavioral compensation (periodic bouts of muscle activity) which presumably served to improve venous return. Despite enhanced ventilatory function, arterial O2 delivery was markedly reduced by hemorrhage, an effect that was due entirely to decrements in cardiac output and hemoglobin level. The disparity between O2 delivery and O2 demand was lessened following resuscitation with 7.5% NaCl/6% Dextran 70, primarily by suppression of demand and secondarily by an augmentation of delivery. (JG)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1989
- Accession Number
- ADA223233
Entities
People
- Carol A. Bossone
- Charles E Wade
- Janis A. Loveday
- John P. Hannon
- Marjorie M. Hunt
Organizations
- Letterman Army Hospital