Interaction of Electromagnetic Fields with Chondrocytes in Gel Culture

Abstract

The research accomplished during this project period focused on control experiments designed to establish whether cartilage cells from normal cartilage will continue to synthesize and accumulate normal extracellular matrix in agarose gel culture. This information is essential to properly design experiments to qualify changes in chondrocyte biosynthesis due to applied electromagnetic fields. The results suggest that both normal chondrocytes and swarm rat chondrosarcoma cells in agarose culture can continue to synthesize matrix macromolecules at a rate similar to or slightly higher than that in normal cartilage; also, that chondrocytes in agarose can successfully mediate assembly and accumulation of normal, mechanically functional extracellular matrix. Keywords: Chondrocytes, Gel, Electromagnetic fields.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1990
Accession Number
ADA223397

Entities

People

  • Alan J. Grodzinsky
  • Michael D. Buschmann
  • Yehezkiel A. Gluzband

Organizations

  • Massachusetts Institute of Technology

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Amino Acids
  • Anabolism
  • Cartilage
  • Cells
  • Chemistry
  • Connective Tissue
  • Connective Tissue Cells
  • Current Density
  • Electrodes
  • Electromagnetic Fields
  • Flow
  • Fluid Flow
  • Fluorescence
  • Macromolecules
  • Molecules
  • Polysaccharides
  • Security

Readers

  • Immunology and Pathology
  • Nanocomposite Materials Science