Recombinant MCF247 Virus, Leukemogenesis, and Immunosuppression in AKR Mice
Abstract
This paper traces the acquisition of the knowledge of thymic leukemia and lymphoma in the AKR mouse system. Early leukemia and lymphoma development in the AKR mouse strain is caused by the genetic recombination of an endogenous retrovirus and a xenotropic retrovirus in the thymic reticuloepithelial cells. This disease state is inevitable in all individuals in a high incidence strain (e.g. AKR), as the retrovirus is integrated into germline and is transmitted by vertical transmission. The use of viral recombinants which only contain part of the parent genome cause decreasing amounts of disease with less of the parent genes. Restriction genes in some mouse strains restrict infection and growth of the retrovirus. Supernatant (SN) from viral recombinant strains of MCF247 virus have a suppressive effect both in vitro and in vivo depending on the amount of parental gene present. Keywords: Recombinant; Leukemogenesis; Immunosuppression; AKR; MCF247 virus; Thymic leukemia; Lymphoma; Theses; Retrovirus; Genetic recombination; Leukemogenic; Viral supernatant.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1990
- Accession Number
- ADA223780
Entities
People
- David A. Reichman
Organizations
- Naval Medical Research Center