Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organophosphate Action

Abstract

We investigated the possible sites of biosynthesis of that pool of acetylcholine (ACh) responsible for the global cerebrovascular vasodilation elicited by electrical stimulation of the cerebellar fastigial nucleus (FN) in anesthetized, paralyzed rats. Sites of ACh biosynthesis were identified immunocytochemically by mapping the distribution of the ACh biosynthetic enzyme choline acetyltransferase (ChAT) by light and electron microscopic immunocytochemistry. Keywords: Acetylcholine, Choline acetyltransferase, Cerebral blood flow, Cerebellum, Fastigial nucleus, Brain stimulation, Muscarinic receptors, Capillary endothelium, Cerebral microvessels.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA224006

Entities

People

  • Constantino Iadecola
  • Donald J. Reis
  • Stephen Arneric

Organizations

  • Cornell University

Tags

Communities of Interest

  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Blood
  • Brain
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Medical Personnel
  • Neural Pathways
  • Neurons
  • Neurosciences

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neuroscience

Technology Areas

  • Microelectronics