Intrinsic Cholinergic Mechanisms Regulating Cerebral Blood Flow as a Target for Organophosphate Action

Abstract

To investigate acetylcholine's (ACh's) role in cardiovascular and cerebrovascular regulation, neuroanatomic substrates were first defined using immunocytochemical mapping from choline acetyltransferase (ChAT), the ACh- synthesizing enzyme. ChAT-immunoreactive cell bodies and processes were localized to autonomic or limbic nuclei throughout the neuraxis and close appositions with brainstem microvessels and ependymal cells. Moreover, they codistributed with catecholaminergic neurons staining for tyrosine hydroxylase (TH) or phenylethanolamine N-methyltransferase (PNMT), overlapped structures rich in muscarinic and nicotinic receptors, and expressed autonomic, neuroendocrine or behavioral responsivity to central cholinergic simulation. Keywords: Acetylcholine, Choline acetyltransferase, Adrenergic neurons, Central neural pathways.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1988
Accession Number
ADA224198

Entities

People

  • David A. Ruggiero
  • Donald J. Reis

Organizations

  • Cornell University

Tags

DTIC Thesaurus Topics

  • Arteries
  • Brain
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Cells
  • Chemistry
  • Neural Pathways
  • Neurons
  • Neurosciences

Fields of Study

  • Biology

Readers

  • Cardiovascular Physiology
  • Neuroscience