Hepatitis B Virus Infection and Hepatocellular Carcinoma: Correlation Between IgM Antibody to Hepatitis B Core Antigen, Hepatitis B e Antigen, and Hepatitis B DNA

Abstract

Sera from 102 black patients with primary hepatocellular carcinoma (PHC) and hepatitis B surface antigenemia were tested for immunoglobulin M antibody against hepatitis B core (IgM anti-HBc), hepatitis B e antigen (HBeAg), and hepatitis B viral (HBV) DNA. Their prevalences were compared to those of a control group of 124 age and sex matched black HBV carriers without tumor. IgM anti-HBc was present in 68.6%, HBeAg in 32.3%, and HBV-DNA in 26.7% of the patients. In the control population, IgM anti-HBc was present in 45%, HBeAg was detected in 3.2%, and HBV-DNA in 25.8%. We conclude that IgM anti-HBc is present appreciably more often than either HBeAg or HBV-DNA in patients with PHC. HBeAg or IgM anti-HBC in serum of HBsAg positive carriers may predict an added risk of PHC development in South African blacks.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1988
Accession Number
ADA224234

Entities

People

  • Ernest Song
  • Geoffrey M. Dusheiko
  • Maria H. Sjogren
  • Michael C. Kew

Organizations

  • Walter Reed Army Institute of Research

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Antibodies
  • Antigens
  • Diseases And Disorders
  • Health Services
  • Hepatitis
  • Infection
  • Liver Diseases
  • Neoplasms
  • South Africa
  • Virus Diseases
  • Viruses
  • Wound Infections

Fields of Study

  • Biology
  • Medicine

Readers

  • Virology (or Medical Virology).
  • Women's Health and Cancer Risk Research: African American Women and Pregnancy Outcomes.