Ninety-Day Subchronic Oral Toxicity Study of Pyridostigmine Bromide in Rats. Volume 1
Abstract
The 90-day subchronic oral toxicity of pyridostigmine bromide was evaluated in male and female Sprague-Dawley rats. Pyridostigmine was administered in the diet at dose levels of 0, 1, 10, 30, 60, and 90 mg/kg/day for 90 days. The addition of pyridostigmine to the diet resulted in dose-related decreases in plasma cholinesterase and erythrocyte acetylcholinesterase activity ranging from 5% to 76% and from 18% to 95%, respectively. Toxic signs associated with the decrease in cholinesterase activity included muscarinic (perianal, perioral, and periocular stains or material, diarrhea, and increased salivation) and nicotinic (hypertonia and tremors) effects. Other signs observed with increased incidence among pyridostigmine-treated animals included irritability, aggression, increased startle reflex, inactivity, jumping, hyperactivity, and chewing. The addition of pyridostigmine to the diet at the 60 and 90 mg/kg/day dose levels resulted in transient reduction in food and water consumption, and correspondingly reduced weight gains for the first two weeks of the study period.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1990
- Accession Number
- ADA224448
Entities
People
- Earl W. Morgan
- Gary M. Zaucha
- Joel B. Seewald
- Paul P. Waring
- Yvonne Letellier
Organizations
- Letterman Army Hospital