Regulation of Glutathione in a Rat Diploid Hepatic Epithelial Cell Line

Abstract

If cells were to elect a 'most valuable player' from among their cytoplasmic constituents, glutathione (GSH) must surely win. Aside from being the most prevalent cellular thiol, it performs feats beyond the grandest expectations for a simple three amino acid peptide. Glutathione has been extensively reviewed and it is not my task to do so again. However, it will be the purpose of this report to investigate some of the mechanisms by which cells produce and maintain their pool of GSH. Toward that end, to follow is a brief outline of the synthesis and metabolism of glutathione and its utility in cellular ecology.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1990
Accession Number
ADA224688

Entities

People

  • Stephen R. Channel

Organizations

  • Air Force Institute of Technology

Tags

DTIC Thesaurus Topics

  • Albumins
  • Amino Acids
  • Biomedical And Dental Materials
  • Cell Line
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Culture Media
  • Culture Techniques
  • Cultured Cells
  • Cytoplasmic Structures
  • Data Analysis
  • Epithelial Cells
  • Neutral Amino Acids
  • Polymeric Films
  • Stem Cells
  • Toxicity

Fields of Study

  • Biology

Readers

  • Molecular Genetics
  • Prostate Cancer Biology.
  • Systems Analysis and Design