The Combination of Atracurium and Vecuronium Compared to Vecuronium Administered Alone: Evaluation of the Time of Onset, Duration of Action, Intubating Conditions, and Cardiovascular Effects

Abstract

Succinylcholine is often used as the neuromuscular relaxant to facilitate endotracheal intubation in the patient presenting for emergency surgery. However, it is contraindicated in some patient subgroups. The purpose of this double blind, randomized study was to investigate the use of the combination of atracurium and vecuronium compared to vecuronium used alone for accomplishing skeletal muscle relaxation to facilitate endotracheal intubation. This study was designed to test the hypotheses that the combination of atracurium 0.40 mg/kg plus vecuronium 0.10 mg/kg (combination group) will result in a significantly shorter onset time and duration of action and will produce better intubating conditions with no differences in cardiovascular effects compared to vecuronium 0.28 mg/kg (vecuronium group) administered alone intravenously.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1990
Accession Number
ADA224703

Entities

People

  • Paul N. Austin

Organizations

  • Air Force Institute of Technology

Tags

DTIC Thesaurus Topics

  • Airway Management
  • Anesthesia
  • Cardiovascular Physiological Phenomena
  • Health Services
  • Heart Rate
  • Institutional Review Board
  • Larynx
  • Medical Personnel
  • New York
  • Peripheral Nervous System
  • Side Effects
  • Surgery

Fields of Study

  • Medicine

Readers

  • Cardiovascular Physiology