Development of Serologic Assays for the Diagnosis of New World Leishmaniasis

Abstract

Genus specific monoclonal antibodies have been generated to 14 different isolates of New World Leishmania. These antibodies have been used to identify closely related subspecies; to recover genus-specific antigens for the development of sero-diagnostic assays; and to identify parasites in infected tissues; to quantitate antigen expression on the surface membrane by flow cytometry. Keywords: Leishmania; Monoclonal antibodies; Amastigotes; Serodiagnosis; Flow cytometry; Immunopathology.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1985
Accession Number
ADA224732

Entities

People

  • Ronald L. Anthony

Organizations

  • University of Maryland School of Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Antigens
  • Biomedical Research
  • Body Fluids
  • Cells
  • Contracts
  • Laboratory Animals
  • Leishmania
  • Leishmaniasis
  • Lymph Nodes
  • Maryland
  • Materials
  • Nanogenerators
  • Parasites
  • Reactivities

Fields of Study

  • Biology

Readers

  • Immunology
  • Infectious Disease/Epidemiology