Virulence Markers of Dengue Viruses

Abstract

Illnesses in humans caused by the four serotypes of dengue virus vary from mild forms i. e. pyrexia of unknown origin (PUO) and dengue fever (DF) to severe forms i.e. dengue hemorrhagic fever and dengue shock syndrome (DHF/DSS). One of the factors that contribute to the DHF and DSS disease outcome is proposed to be the variation in the virulence of dengue viruses. We initially evaluated monocyte-infectivity as a marker the for virulence of dengue-2 virus by testing 72 dengue-2 viral isolates associated with PUO/DF and DHF/DSS obtained from eight geographic locations for their ability to infect and multiply in freshly isolated human monocytes. Dengue-2 viral isolates from DHF/DSS patients exhibited a higher monocyte-infectivity than that of the isolates from PUO or DF patients. Statistical analyses of the data indicated a correlation between the probability of a dengue-2 viral isolate causing DHF/DSS and the viral infection in human monocytes in the presence of dengue enhancing antibodies. Keywords: Dengue viruses, Dengue hemorrhagic fever, Virulence, Virulence marker, Monocytes.

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Document Details

Document Type
Technical Report
Publication Date
Feb 20, 1990
Accession Number
ADA224755

Entities

People

  • James L. Hardy
  • Srisakul C. Kliks

Organizations

  • University of California, Berkeley

Tags

DTIC Thesaurus Topics

  • Animal Diseases
  • Body Fluids
  • Cell Physiological Processes
  • Cells
  • Correlation Analysis
  • Dengue
  • Disease Outbreaks
  • Genetic Variation
  • Health Services
  • Infectious Diseases
  • Medical Personnel
  • Proteins
  • Regression Analysis
  • Virus Diseases
  • Viruses

Fields of Study

  • Biology
  • Medicine

Readers

  • Virology (or Medical Virology).