Immunological Approach to the Identification and Development of Vaccines to Various Toxins

Abstract

Monoclonal antibodies specific for saxitoxin and tetrodotoxin with higher binding affinities than those generated under this contract are still being sought for. Attempts to generate internal image monoclonal anti-idiotypic antibodies specific for the highest binding anti-saxitoxin and anti-tetrodotoxin antibodies are continuing. A monoclonal anti-idiotypic antibody, designated DE8, specific for a protective anti-mycotoxin T-2 monoclonal antibody (HD11) was generated. Administration of DE8 into syngeneic BALB/c mice induced a protective antibody response against the in-vitro and in-vivo toxicity of T-2. Keywords: Anti-idiotype vaccine, In-vitro and in-vivo protection against toxicity, Monoclonal anti-idiotype antibody.

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Document Details

Document Type
Technical Report
Publication Date
Jun 18, 1990
Accession Number
ADA225047

Entities

People

  • Deborah Armstrong
  • Ronald C. Kennedy
  • Tran C. Chanh

Organizations

  • Texas Biomedical Research Institute

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Antibodies
  • Biological Toxins
  • Biomedical Research
  • Cells
  • Classification
  • Contracts
  • Fungi
  • Immunity
  • Inhibitors
  • Laboratory Animals
  • Membranes
  • Molecular Weight
  • Mycotoxins
  • Peripheral Nervous System
  • Security
  • Tissues

Fields of Study

  • Biology

Readers

  • Immunology
  • Mycotoxin ecology in Amazonian ecosystems.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech