Ultrastructural Study of the Effect of Polyctfe on Primate Liver

Abstract

Oligomers of chlorotrifluoroethylene (POLYCTFE) have been found to possess excellent properties as lubricants and hydraulic fluids. The 3l1 oil, consisting primarily of oligomers of 3 and 4 units, is a candidate base stock for nonflammable hydraulic fluids for advanced aircraft. Unfortunately, ultrastructural studies of the livers from rats exposed to vapors of POLYCTFE for 90-days revealed an increase in the number of peroxisomes, dose-dependent mitochondrial swelling and a dose-dependent increase in smooth endoplasmic reticulum. In order to determine the relevance of the effect of POLYCTFE on rat livers to human livers, four male rhesus monkeys weighing 8 to 10 kg were dosed by gavage daily for 15 days with 0.725 g/kg POLYCTFE for 15-days resulted in only minor changes in the hepatocytes. There was no evidence of peroxisomal proliferation in exposed primate livers. Keywords: Toxicity, Primates, Liver, Halogenated, Hydrocarbons, Electron microscopy.

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1990
Accession Number
ADA225250

Entities

People

  • D. R. Mattie
  • J. J. Maslanka
  • M. R. Chase

Organizations

  • Armstrong Laboratory

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Aircrafts
  • Animal Structures
  • Animals
  • Cell Physiological Processes
  • Cells
  • Cytoplasmic Granules
  • Electron Microscopes
  • Electron Microscopy
  • Electrons
  • Endoplasmic Reticulum
  • Epithelial Cells
  • Fluids
  • Hydraulic Fluids
  • Microscopy
  • Oligomers
  • Rhesus Monkeys

Readers

  • Internal Combustion Engine (ICE) Technology.
  • Toxicology/Environmental Toxicology

Technology Areas

  • Microelectronics