Effects of Immunomodulatory Drugs on T Lymphocyte Activation and Function
Abstract
This is the final report for contract DAMD 17-86-C-6166. During the contract period several drugs provided to us by the U.S. Army Medical Research and Development Command were tested for their immunoregulatory properties. After an initial screening only seven of the drugs displayed profiles that justified further evaluation of their immunoregulatory properties. These drugs were CL246 , FK565, IFNa, AVS1300, AVS1761, AVS2149, and AVS2776. CL246 was immunosuppressive for all responses tested, FK565 stimulated lL1 production, IFN a inhibited surface la expression and at a narrow dose range stimulated PWM- induced IgM production. This drug had a biphasic effect, dependent on its dose, on LAK generation, but had no effect on CTL generation. The properties of this drug suggest a selective effect on T cell-dependent responses. AVS1761 was found to inhibit ConA proliferation, la and lL2 receptor expression, and LAK generation. AVS2149 and AVS2776 inhibited lL2 receptor and la expression respectively. Based on the observed properties of the above drugs, CL246, FK565, and AVS1300, warrant further investigation. These drugs seem to be good in vitro probes for studies of the immune system and have the potential of becoming useful clinical agents.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 01, 1989
- Accession Number
- ADA225770
Entities
People
- Constantine D. Tsoukas