At-Resin Research: Biotechnical Support and Heterogeneous Catalysis
Abstract
Four additional batches of polyethylene (PE)-supported palladium catalyst were prepared. These catalysts have been evaluated for the preparation of a diynol addition product 2 starting from 4,4-bis(3-bromophenoxy) diphenyl sulfone 1 (Figure 1). Palladium still leaches into the product. The reaction conditions of palladium complexation with triphenyl phosphine (TPP) were studied. The optimum amount of TPP required in the diynol addition reaction was lowered to a range of one-half as compared to the established procedures. Under the Biotech-Support part of this program, reaction conditions favoring condensation of phenols and aromatic halides were explored using model reactions of m-cresol and dichlorodiphenyl sulfone and difluorobenzophenone. Condensation reactions were faster in the presence of 18-Crown-6 than CsI. Difluorobenzophenone reacted faster than dischlordiphenyl sulfone with m-cresol. The reaction conditions were applied to the condensation of m-hydxroxphenyl acetylene and aromatic dihadlides.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 20, 1990
- Accession Number
- ADA226076
Entities
People
- Yesh P. Sachdeva