Analysis of Saxitoxin from Urine Using Dynamic FAB/MS

Abstract

Analytical procedures for the analysis of saxitoxin (STX) have been investigated using Continuous Flow Fast Atom Bombardment (CFFAB). Items investigated included derivative formation of STX resolution by micro capillary open tube columns (25 to 100 microns i.d.), CFFAB matrices, solvent flow rates, probe tip design and selection of fragment ions for analysis by Selected Ion Recording. Five-hundred picograms of STX can be reproducibly detected by SIR using a matrix made up of 5% thioglycerol, 1% acetic acid and 0.05% sodium dodecyl sulfate. Keywords: RA 1, BD, Lab animals, Guinea pigs, Rats, Saxitoxin, Dynamic FAB, Analysis, Mass spectrometer.

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Document Details

Document Type
Technical Report
Publication Date
Jul 31, 1990
Accession Number
ADA226474

Entities

People

  • Chester J. Mirocha
  • Hamed Abbas
  • Won J. Cheong

Organizations

  • University of Minnesota

Tags

Communities of Interest

  • Advanced Electronics
  • Biomedical
  • Ground and Sea Platforms

DTIC Thesaurus Topics

  • Acetic Acid
  • Alcohols
  • Capillary Electrophoresis
  • Chemical Synthesis
  • Chemistry
  • Chlorides
  • Crystal Structure
  • Fish
  • Flow Rate
  • Liquid Chromatography
  • Mass Spectra
  • Mass Spectrometers
  • Mass Spectrometry
  • Materials Science
  • Optical Materials
  • Organic Chemistry
  • Spectrometry

Readers

  • Analytical Chemistry
  • Molecular and Cellular Biochemistry