Extrathalamic Modulation of Cortical Function

Abstract

The overall goal of these studies is to characterize the effects of noradrenergic (NA) afferents on cortical information processing. Our previous studies indicate that the primate locus coeruleus (LC) system, originating in the pontine brainstem, innervates neocortex more densely than previously thought, exhibiting highly specific patterns in terms of the regional and laminar distribution of its axons across the neocortex. Previous neurophysiological observations suggest that this highly divergent system imposes state-related modulatory effects on thalamo-cortical and cortico- cortical systems. For example, we have shown that primate LC-NA neurons are more active during waking than sleep and exhibit bursts of activity during increases in attentiveness. Keywords: Locus coeruleus, noradrenergic, Event-related potential.

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Document Details

Document Type
Technical Report
Publication Date
Jul 27, 1990
Accession Number
ADA226786

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  • Stephen L. Foote

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  • University of California, San Diego

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