Relationship of Selected Functions of Activated Macrophages
Abstract
The objective of this project was to examine relationships of selected metabolic capabilities and key immunological functions of activated marcrophages. Consistent association or a single example of dissociation between two parameters would indicate or eliminate the possibility of common induction pathways or functional interdependence of these parameters. Results indicate that thiol production, capacity to produce H2O2, and tumor cytotoxicity are often induced by the same stimuli, but, in one case, H2O2 production was not affected by stimuli which increased the other two parameters. The commonly accepted idea that highly activated (tumoricidal) macrophages are poor antigen processing and presenting cells was confirmed, but some tumoricidal activity was noted in macrophages which were excellent antigen processing and presenting cells. Keywords: Macrophage, Nitric oxide, Nitrite, Nitrate, Tumor cytolysis, Listeria monocytogenes, Immunotoxicology.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 10, 1990
- Accession Number
- ADA226849
Entities
People
- Stephen B. Pruett
Organizations
- Mississippi State University