Antigenic Structure of Coxiella burnetii: A Comparison of Lipopolysaccharide and Protein Antigens as Vaccines against Q Fever

Abstract

Immunization with inactivated phase I Coxiella burnetii whole cells protects animals and humans against experimental and natural Q fever. The characterization of C. burnetii membrane antigens that play a role in the development of immunity revealed phase I lipopolysaccharide (LPSI) and a large number of proteins as possible vaccine candidates. A new vaccine prepared from the residue of chloroform-methanol-extracted phase I cells (CMRI) is efficacious in animals. However, immunization with carrier-linked, recombinant DNA-produced or synthetic peptide subunit vaccines derived from protective epitopes of C. burnetii is highly desirable. Alternatives to the protein-based strategies include the use of the C. burnetii non-toxic LPSI to provide efficacious immunomodulation and productive epitopes. The studies described here may facilitate the identification of protective protein or LPSI epitopes as target(s) for Q fever vaccine development.

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Document Details

Document Type
Technical Report
Publication Date
Jun 26, 1990
Accession Number
ADA226911

Entities

People

  • C. R. Bolt
  • D. M. Waag
  • J. C. Williams
  • N. Banerjee-bhatnagar
  • T. A. Hoover

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Amino Acids
  • Animals
  • Antigens
  • Blood
  • Cells
  • Cellular Structures
  • Health Services
  • Immunity
  • Immunization
  • Immunogenicity
  • Immunomodulation
  • Lymphatic System
  • Lymphocytes
  • Microorganisms
  • Q Fever
  • Rodents
  • Vaccines

Fields of Study

  • Biology

Readers

  • Immunology

Technology Areas

  • Biotechnology