Synthesis and Antiviral Evaluation of Pyrazofurin Analogues
Abstract
Two 4-deoxy- and two 4-homopyrazofurin derivatives have been prepared via 1,3-dipolar cycloaddition reactions. These analogues have been submitted to the Army for antiviral analysis and have formed the basis of three publications submitted to the professional literature and one paper presented at a professional meeting. Synthetic methods have also been developed that can be anticipated to lead to pyrazofurin nor-amide, various pyrazofurin amides, 2- deazapyrazofurin, and 1-deazapyrazofurin during the coming year. Negotiations between Eli Lilly Company, the U.S. Army, and the University of South Florida were begun this year and are expected to lead to a supply of pyrazofurin from Lilly for this project. This will expedite the synthesis of pyrazofurin analogues with variation in the ribofuranosyl moiety. (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 19, 1990
- Accession Number
- ADA227154
Entities
People
- Stewart W. Schneller
Organizations
- University of South Florida