Stereospecificity of Antidotes and Their Mechanism of Action in Intoxications with Organophosphorus Anticholinesterases

Abstract

Our program during the last year has mainly been concerned with studies on: the effect of diazepam on 1-hyoscyamine binding in the old stock of sick and healthy mice and new stock of healthy mice, the usability of 1- hyoscyamine binding for studies of specific receptor distribution in brain, effect of different combinations of antagonists (1-hyoscyamine, diazepam, H1-6) on acetycholine turnover, and duration of the effect of diazepam on acetylcholine turnover. There is a significant difference between the old and new stock of mice as far as the influence of diazepam on 1-hyoscyamine binding is concerned. In order that optimal parameters can be determined, therefore, the model needs further development in the new stock of mice. Keywords: Acetylcholine, Choline, Diazepam, Hyoscyamine, HI-6, Cholinesterase inhibitors, RA 5.

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Document Details

Document Type
Technical Report
Publication Date
Feb 01, 1990
Accession Number
ADA227239

Entities

People

  • Bo. Holmstedt
  • Bo. Karlen
  • Ingrid. Nordgren
  • Lena. Palmer

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Anticonvulsants
  • Antidotes
  • Biomedical Research
  • Chlorides
  • Chromatography
  • Classification
  • Displacement
  • Enzyme Inhibitors
  • Gas Chromatography
  • Intoxication
  • Laboratory Animals
  • Mass Spectrometry
  • Pharmacology
  • Security
  • Spectrometry

Fields of Study

  • Biology

Readers

  • Library and Information Science/ Studies, Southeast Asia Studies, Bibliography of Vietnam and Lao Studies.
  • Logistics and Supply Chain Management.
  • Neurotoxicology