Radioprotectants and Gastric Function

Abstract

The objectives of this project, therefore are to evaluate (1) the emetic properties of radioprotectants of the WR2721 family in monkeys in relation to modifications of gastrointestinal motility; (2) the role of the area postrema in WR2721-induced vomiting and gastric suppression; and (3) the possibility of preventing the side effects of radioprotectants with antiemetics. During this period the investigators have continued to study the emetic effects of WR2721 in monkeys, and have measured the concurrent action of this radioprotectant ongastic motility and gastric emptying of liquids and solids. In addition, they have determined the role of the area postrema in WR2721-induced vomiting and gastric suppression in beagle dogs. Finally, they evaluated the possibility of preventing WR2721-induced vomiting with zacopride. (js0

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Document Details

Document Type
Technical Report
Publication Date
Jan 15, 1990
Accession Number
ADA227447

Entities

People

  • Andre Dubois

Organizations

  • Uniformed Services University of the Health Sciences

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Animals
  • Birds
  • Brain
  • Classification
  • Computer Programs
  • Computers
  • Electrodes
  • Health Services
  • Intestines
  • Medical Personnel
  • Prostheses And Implants
  • Radiation
  • Security
  • Side Effects
  • Skull
  • Small Intestine

Readers

  • Forest Ecology
  • Systems Analysis and Design
  • Toxicology/Environmental Toxicology