Biology of Immunomodulators
Abstract
During this contract period we have examined approximately 25 immunomodulating drugs for their ability to stimulate various components of the specific and nonspecific immune systems as well as their ability to enhance resistance to influenza, herpes-, arena-, bunya- and flaviviruses. All of these compounds were able to stimulate at least one component of the immune system and some were able to stimulate many. Although there was no correlation between stimulation of a particular component of the immune system and resistance to virus infection, in general, drugs that were most efficacious, appeared to stimulate a broader range of immune functions. Thus, we were able to rank immunomodulators based on their ability to stimulate a variety of immune functions and viral resistance. This ranking has enabled us to select several promising drugs as potential candidates for further evaluation and use in man. These drugs include: Poly I:C-LC, (poly riboinosinic:poly ribocytidylic acid complexed with carboxymethyl cellulose and poly-L-lysine); CL 246738, 3,6-BIS(2- (piperidinoethoxy)acridine (trihydrochloride); Ampligen, (a mismatched analog of poly riboinosinic:poly ribocytydylic acid); the pyrimidinone ABPP, ((2)-amino- (5)bromo-(6)-phenyl-(4) (3H)- pyrimidinone ; the Riker-3M compound (1-(2-methyl propyl)-1H-imidazo(4,5-C)quinolin 4-amine and a hybrid recombinant human interferon (rhuIFNalpha-B/D). (js)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1990
- Accession Number
- ADA227460
Entities
People
- Abdul Ghaffar
- Eugene P. Mayer
- J. D. Gangemi
Organizations
- University of South Carolina