Antibody to the RNA-Dependent DNA Polymerase of HTLV-III: characterization and Clinical Associations
Abstract
Epitopes related to the HIV-1 polymerase important both to the identification of in vitro cellular responses correlating with disease progression, and as targets for immune intervention in HIV infection were explored. Additional serum samples from individuals at various WRAIR stages of HIV infection were examined. Synthetic peptides were prepared from nucleotide sequences of HIV pol regions homologous to the catalytic sites of other mammalian polymerases. A statistically significant but imperfect correlation was found between the presence of antibodies capable of blocking the catalytic activity of RT and and anti peptide II and IV. Keywords: AIDS, Clinical, HTLV-III, Infectious diseases.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 31, 1988
- Accession Number
- ADA227519
Entities
People
- Jeffrey Laurence
Organizations
- Cornell University